Spontaneous Nanoparticle Formation From a Fluorescent Nucleoside Analogue

Bulletin of the Korean chemical society

Dohyun Moon¹  Byeang Hyean Kim¹  Eun-Kyoung Bang¹ 

关键词: Nucleosides;    Hydrogen bonding;    Self-assemblies;    Nanoparticles;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A fluorescent nucleoside analogue, AC, featuring two non-complementary nucleobases linked through an ethynyl group, was synthesized. The extended π-conjugation imparts AC with red-shifted absorbance (relative to adenine and cytosine) and pale-blue fluorescence. It spontaneously forms nanoparticles, which exhibit considerably enhanced fluorescence, without the help of any additional stabilizing agent. The DMSO/water ratio was an important factor influencing the construction of the NPs. X-ray crystallography confirmed the structure of AC; dynamic light scattering and scanning electron microscopy confirmed the existence of the nanoparticles.

【 授权许可】

Unknown