Preparation of Fully Substituted 1,3,4-Oxadiazole Derivatives from N-Isocyaniminotriphenylphosphorane, (E)-Cinnamic Acids, Chloroacetone and Primary Amines

Bulletin of the Korean chemical society

Zahra Karimi¹  Ali Ramazani¹  Fatemeh Zeinali Nasrabadi¹  Morteza Rouhani¹ 

关键词: N-Isocyaniminotriphenylphosphorane;    Chloroacetone;    (E)-Cinnamic acid;    1;    3;    4-Oxadiazole;    aza-Wittig reaction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The 1:1 imine intermediate generated by the addition of primary amine to chloroacetone is trapped by Nisocyaniminotriphenylphosphorane in the presence of (E)-cinnamic acids and the corresponding iminophosphorane intermediate was formed. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed in neutral conditions at room temperature. The disubstituted 1,3,4-oxadiazole derivatives were produced in excellent yields.

【 授权许可】

Unknown