Synthesis of Tetrazolo[1,5-a]quinoxaline based Azetidinones & Thiazolidinones as Potent Antibacterial & Antifungal Agents

Bulletin of the Korean chemical society

M. Shaquiquzzaman¹  Rizwan Azim¹  Atul Khurana¹  Ozair Alam¹  Waquar Ahsan¹  S. A. Khan¹  Nadeem Siddiqui¹  Shiv Kumar¹ 

关键词: Tetrazolo[1;    5-a]quinoxaline;    Thiazolidinones;    Azetidinones;    Antibacterial;    Antifungal;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

4-Chlorotetrazolo[1,5-a]quinoxaline (III) was synthesized by azide (2+3) cycloaddition of 2,3-dichloroquinoxaline (II). Compound (III) on further refluxing with hydrazine hydrate furnished 4-hydrazinotetrazolo[1,5- a]quinoxaline (IV). Further refluxing of (IV) with different aromatic aldehydes in methanol yielded corresponding Schiff’s bases V(a-j). Various 4-aminotetrazolo[1,5-a]quinoxaline based azetidinones VII(a-j) were synthesized by stirring the compounds V(a-j), at low temperature, with equimolar mixture of chloroacetylchloride & triethylamine in dry benzene, while 4-aminotetrazolo[1,5-a]quinoxaline based thiazolidinones VIII(a-j) were synthesized by refluxing Schiff’s bases V(a-j) with thioglycolic acid in oil-bath. The structures of all the compounds were confirmed on the basis of 1H-NMR & FT-IR spectral data. All the newly synthesized compounds were screened for in-vitro antimicrobial activity against E. coli, S. aureus, K. pneumoniae & P. aeruginosa & antifungal activity against C. albicans. Few of them have exhibited the promising activity.

【 授权许可】

Unknown