Highly Selective Synthesis of β-Amino Carbonyl Compounds over ZSM-5-SO3H under Solvent-free Conditions

Bulletin of the Korean chemical society

Roozbeh Javad Kalbasi¹  Ahmad Reza Massah¹  Neda Samah¹ 

关键词: Mannich-reaction;    -Amino carbonyl compound;    ZSM-5-SO3H;    Solvent-free;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

ZSM-5-SO3H efficiently catalyzed the one-pot three-component Mannich reaction of aldehydes, anilines, and ketones. β-Aminocarbonyl compounds were obtained in reasonable yields and excellent stereoselectivities when the reaction was carried out at room temperature under solvent-free conditions. Simple experimental conditions and product isolation procedure makes this protocol potential for the development of clean and environment-friendly strategy for the synthesis of β-amino-ketones. The catalyst was recovered and reused for subsequent runs.

【 授权许可】

Unknown