Chemical Modification of Rupestonic Acid and Preliminarily In Vitro Antiviral Activity Against Influenza A3 and B Viruses

Bulletin of the Korean chemical society

Haji Akber Aisa¹  Jian ping Yong¹ 

关键词: Synthesis;    Rupestonic acid ester derivatives;    Anti-influenza virus;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

To improve the biological activities of rupestonic acid, 21 new rupestonic acid fatty ester derivatives (2a-2h) and aromatic ester derivatives (2i-2u) were synthesized and preliminarily evaluated for their anti-influenza activity in vitro by the national center for drug screening of China, using the Oseltamivir and Ribavirin as reference drugs. The results showed that 2l (IC50 = 0.5 μmol/L) exhibited potent anti-influenza A3 viral activity among the synthesized compounds and was 10-fold more potent than that of the reference drug Oseltamivir (IC50 = 5.1 μmol/L).

【 授权许可】

Unknown