Thiadiazole Derivatives as Potential Anticonvulsant Agents

Bulletin of the Korean chemical society

Ozair Alam¹  Surajpal Verma¹  Pooja Mullick¹  Suroor A. Khan¹ 

关键词: Thiadiazole;    Thiazolidin-4-one;    Anticonvulsant activity;    Neurotoxicity;    MES model;    Rotarod method;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR,1H NMR,13C NMR and mass spectral data confirmed the structure of the synthesized compounds. The derivatives of these moieties were evaluated for anticonvulsant activity by MES model and neurotoxicity by rotarod method. The synthesized compounds showed good potential for anticonvulsant activity besides this, the compounds also showed neurotoxic effect. It was observed that compounds with OCH3 at 3, 4 position of phenyl ring [5(a-l)] showed less protection against convulsions as compared to compounds having unsubstituted phenyl ring [4(a-l)].

【 授权许可】

Unknown