Dynamic Research of a Potential Carrier for Hydrophobic Compound Model Pyrene Using Amphiphilic Peptide EYK

Bulletin of the Korean chemical society

Xiao jun Zhao¹  Liang Wang¹ 

关键词: Amphiphilic peptide EYK;    Pyrene;    Hydrophobic compound carrier;    Fluorescence spectroscopy;    Dynamic process;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In recent years, the study of self-assembly peptide used in drug delivery system has been attracted great interest from scientists. In the category are self-assembly peptides in the structure either with one hydrophobic surface and another hydrophilic or a hydrophobic head and a hydrophilic tail. Here, we focus on a novel designed peptide EYK with double amphiphilic surfaces, investigating on the capability of peptide as a carrier for hydrophobic compound model pyrene. The fluorescence data presented the dynamic process of the transfer, showing that the pyrene was in the crystalline form in peptide solution, and molecularly migrated from its peptide encapsulations into the membrane bilayers when the peptide-pyrene suspension was mixed with liposome vesicles. The results indicated that the peptide EYK could stabilize hydrophobic pyrene in aqueous solution and delivered it into EPC liposome as a potential carrier.

【 授权许可】

Unknown