Solid-Phase Synthesis of Unfunctionalized Arenes Via the Traceless Cleavage of Sulfonate Linkers

Bulletin of the Korean chemical society

Chul-Hee Cho¹  Kwangyong Park¹  Min Jy Jo¹  Chul-Bae Kim¹ 

关键词: Solid-phase synthesis;    Traceless cleavage;    Parallel synthesis;    Unfunctionalized arenes;    Sulfonate linker;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The hydrogenolysis of polymer-bound arenesulfonates by 2-propylmagnesium chloride was performed through reductive cleavage of the C−S bond in the presence of a nickel catalyst. The reaction underwent in the highest efficiency by adding 15 equiv of the nucleophile in two additions with dppfNiCl2 in THF. Various unfunctionalized naphthalene, biphenyl, and stilbene derivatives were produced in good yields by the traceless sulfonate linker system at room temperature.

【 授权许可】

Unknown