Spectrofluorimetric Determination of Bisphosphonates in Biological Samplewith a Fluorescent Chemosensor, NadDPA-2Zn2+

Bulletin of the Korean chemical society

Songhie An¹  Yeonsoon Chio¹  A reum Jeong¹  Geun woo Jin¹  Yunseong Jeong¹  Jae Han Lee¹  Jong In Hong¹  Soon Young Kim¹  Jong Sang Park¹ 

关键词: Chemosensor;    Fluorescent chemosensor;    Bisphosphonate;    Alendronate;    Risedronate;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The accurate determination of bisphosphonate levels in bone and biological fluids is important in both clinical and pharmacological/toxicological studies; however, the quantitative analysis of the bisphosphonate is difficult because its concentration is quite low in most of biological sample. A novel fluorescent chemosensor (FCS)-based measurement method of bisphosphaonate levels using Naphta-diDPA-2Zn2+ (NadDPA-2Zn2+, DPA = dipycolylamine), an excellent FCS previously used for detecting PPi, was developed. By the FCS method, the concentration of bisphosphonates having no fluorophores can be determined analyzed with sufficient sensitivity. The results of this study indicate that the FCS-based measurement can be a useful method to analyze bisphosphonates in biological samples.

【 授权许可】

Unknown