Design and Synthesis of Metallopeptide Sensors: Tuning Selectivity with Ligand Variation

Bulletin of the Korean chemical society

Keun Hyeung Lee¹  Joung Min Kim¹  Bishnu Prasad Joshi¹ 

关键词: Peptides;    Zn2+;    Cd2+;    Peptide sensor;    Chemical sensor;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

We chose a fluorescent pentapeptide sensor (-CPGHE) containing a dansyl fluorophore as a model peptide and investigated whether the selectivity and sensitivity of the peptides for heavy and transition metal ions could be tuned by changing amino acid sequence. In this process, we developed a selective peptide sensor, Cp1-d (-HHPGE, Kd = 670 nM) for detection of Zn2+ in 100% aqueous solution and a selective and sensitive peptide sensor, Cp1-e (-CCHPGE, Kd = 24 nM) for detection of Cd2+ in 100% aqueous solution. Overall results indicate that the selectivity and sensitivity of the metallopeptide sensors to specific heavy and transition metal ions can be tuned by changing amino acid sequence.

【 授权许可】

Unknown