An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazineDerivatives Catalyzed by Zirconyl(IV) Chloride and Evaluationof its Biological Activities

Bulletin of the Korean chemical society

Murlidhar S Shingare¹  Atul H Kategaonkar¹  Rajkumar U Pokalwar¹  Amol H Kategaonkar¹  Swapnil S Sonar¹  Bapurao B Shingate¹ 

关键词: 1;    3-Oxazines;    Zirconyl(IV) chloride;    Grinding;    Antibacterial;    Antifungal;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity.

【 授权许可】

Unknown