Synthesis of Benzoxazole Amides as Novel Antifungal Agentsagainst Malassezia Furfur

Bulletin of the Korean chemical society

Young Kook Kim¹  Hea Young Park Choo¹  Jinah Kim¹  Soon Yong Choi¹  Beom Joon Kim¹ 

关键词: Benzoxazole amides;    Antifungal;    Malassezia furfur;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis-methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.

【 授权许可】

Unknown