Chemical Constituents from Acer mandshuricum and Their Effects on the Function of Osteoblastic MC3T3-E1 Cells

Bulletin of the Korean chemical society

Eun Mi Choi¹  Jeong Ah Kim¹  Young Ho Kim¹  Yan Ding¹  Chun Liang¹  Huu Tung Nguyen¹ 

关键词: Acer mandshuricum;    Aceraceae;    4-Methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside;    Osteoblast differentiation;    MC3T3-E1 cell;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new compound, 4-methoxyl 5-hydroxymethyl benzoic 3-O-β-D-glucopyranoside (1), has been isolated from the leaves and stems of Acer mandshuricum, along with nine known compounds (2-10). Their structures were determined by a variety of spectroscopic analyses. The effect of compounds 1-10 on the function of osteoblastic MC3T3-E1 cells was examined by determining alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization. Compound 1 significantly increased the function of osteoblastic MC3T3-E1 cells; 5.0 μM of 1 increased ALP activity, collagen synthesis, and mineralization of MC3T3-E1 cells to 114.7, 119.5, and 108.2% (P < 0.05) of the basal value, respectively. In addition, compounds 2-10 also potently increased the function of osteoblastic MC3T3-E1 cells.

【 授权许可】

Unknown