期刊论文详细信息
Bulletin of the Korean chemical society | |
Highly Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by Novel Chiral tert-Amino Alcohols |
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Cong hai Zhang1  Jun Lin1  Sheng qiang Pan1  Rong Huang1  Sheng jiao Yan1  | |
关键词: Amino alcohol; Asymmetric addition; Aldehydes; Alkylation; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
A series of novel chiral tert-amino alcohols 4a-h derived from enantiomerically pure phenylalanine were synthesized efficiently and used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc (diethylzinc- to-aldehyde addition). The use of 10 mol % of the amino alcohols led to the corresponding sec-alcohols with excellent enantioselectivities (up to 100% ee) and high yields.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010242162ZK.pdf | 323KB | download |