Highly Enantioselective Addition of Diethylzinc to AldehydesCatalyzed by Novel Chiral tert-Amino Alcohols

Bulletin of the Korean chemical society

Cong hai Zhang¹  Jun Lin¹  Sheng qiang Pan¹  Rong Huang¹  Sheng jiao Yan¹ 

关键词: Amino alcohol;    Asymmetric addition;    Aldehydes;    Alkylation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A series of novel chiral tert-amino alcohols 4a-h derived from enantiomerically pure phenylalanine were synthesized efficiently and used as chiral ligands in the catalytic enantioselective ethylation of aldehydes with diethylzinc (diethylzinc- to-aldehyde addition). The use of 10 mol % of the amino alcohols led to the corresponding sec-alcohols with excellent enantioselectivities (up to 100% ee) and high yields.

【 授权许可】

Unknown