Supramolecular Micelle from Amphiphilic Mn(III)-porphyrin Derivatives as a Potential MRI Contrast Agent

Bulletin of the Korean chemical society

Do Hyung Lee¹  Kwangmo Choi¹  Woo Dong Jang¹ 

关键词: Porphyrin;    Self-assembly;    Micelle;    MRI;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Amphiphilic porphyrin derivatives have been synthesized and characterized by 1H NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UVvis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The T1 relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a T1 contrast agent.

【 授权许可】

Unknown