Rhodium-Catalyzed Reductive Decyanation of Nitriles Using Hydrosilane as a Reducing Agent: Scope, Mechanism and Synthetic Application

Bulletin of the Korean chemical society

Ryo Nakamura¹  Yusuke Kita¹  Mamoru Tobisu¹  Naoto Chatani¹ 

关键词: Reductive decyanation;    Carbon-carbon bond activation;    Rhodium catalyst;    Hydrosilane;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A rhodium-catalyzed reductive cleavage reaction of carbon-cyano bonds is developed using hydrosilane as a mild reducing agent. A wide range of nitriles, including aryl, benzyl, and �?-hydrogen containing alkyl cyanides are applicable to this decyanation reaction. The method is also applicable to organic synthesis, in which benzyl cyanide is used as a benzyl anion equivalent and a cyano group functions as a removable ortho-directing group.

【 授权许可】

Unknown