Silica Supported Tungstosilicic Acid as an Efficient and Reusable Catalyst for the One-Pot Synthesis of β-Acetamido Ketones via a Four-Component Condensation Reaction

Bulletin of the Korean chemical society

Masoud Nasr Esfahani¹  Tahere Gholampour¹  Morteza Montazerozohori¹ 

关键词: -Acetamido ketone;    Silica supported tungstosilicic acid;    Four-component;    Dakin-West reaction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Silica supported tungstosilicic acid has been used as an effective catalyst for a modified Dakin-West one-pot, fourcomponent condensation of an aryl aldehyde, an aryl ketone, acetyl chloride and acetonitrile for the synthesis of β-acetamido ketones. This catalytic system can act as an active, inexpensive, recoverable and recyclable catalyst. Some advantages of this system are short reaction times, good to excellent yields, easy work up and the ability to be carried out at the large scale reactions.

【 授权许可】

Unknown