Total Synthesis of (¡¾)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone

Bulletin of the Korean chemical society

Hyun Kyu Cho¹  Cheon Gyu Cho¹  Nguyen Thanh Tam¹ 

关键词: Total synthesis;    Aspidospermidine;    Diels-Alder reaction;    3;    5-Dibromo-2-pyrone;    Tandem reaction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new synthetic route to (�?)-aspidospermidine was devised, starting from the cycloadduct of 3-ethyl-5-bromo-2- pyrone with vinyl sulfide through a tandem conjugate addition-alkylation sequence. The requisite 3-ethyl-5-bromo-2- pyrone was prepared via the C3-selective Pd-catalyzed coupling reaction with Et₃Al-dimethylaminoethanol complex.

【 授权许可】

Unknown