Wet SiO2 As a Suitable Media for Fast and Efficient Reduction of Carbonyl Compounds with NaBH3CN under Solvent-Free and Acid-Free Conditions

Bulletin of the Korean chemical society

Behzad Zeynizadeh¹  Mehri Kouhkan¹ 

关键词: NaBH3CN;    Wet SiO2;    Solvent-free;    Microwave irradiation;    Reduction;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Reduction of carbonyl compounds such as aldehydes, ketones, �?,�?-unsaturated enals and enones, �?-diketones and acyloins was carried out readily with NaBH₃CN in the presence of wet SiO₂ as a neutral media. The reactions were performed at solvent-free conditions in oil bath (70 - 80 ^oC) or under microwave irradiation (240 W) to give the product alcohols in high to excellent yields. Regioselective 1,2-reduction of conjugated carbonyl compounds took place in a perfect selectivity without any side product formation.

【 授权许可】

Unknown