Detection of Small Neutral Carbohydrates Using Various Supporting Materials in Laser Desorption/Ionization Mass Spectrometry

Bulletin of the Korean chemical society

Jeongkwon Kim¹  Woong Kim¹  Hyo Jik Yang¹  Myung Ki Lee¹  Aera Lee¹ 

关键词: Carbohydrate;    Laser desorption ionization;    Ionic liquid matrix;    MALDI;    Binary matrix;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A comprehensive comparative investigation of small carbohydrates in laser desorption ionization was performed on supporting materials composed of sodiated 2,5-dihydroxybenzoic acid (DHB), carbon nanotubes, an ionic liquid matrix of DHB-pyridine, a binary matrix of DHB-aminopyrazine, zinc oxide nanoparticles, and gold nanoparticles. The abundance of [M+Na]+ ions, where M is glucose or sucrose, was compared for each supporting material. The highest sensitivity for both glucose and sucrose, with a detection limit of 3 pmol, was observed with carbon nanotubes. Both carbon nanotubes and the ionic liquid matrix exhibited the highest reproducibility.

【 授权许可】

Unknown