Enantioselective Fluorination of ¥â-Keto Phosphonates and ¥â-Ketoesters Catalyzed by Chiral Palladium Complexes

Bulletin of the Korean chemical society

Dae Young Kim¹  Sun Mi Kim¹  Na Ri Lee¹ 

关键词: Chiral palladium complexes;    Electrophilic fluorination;    Asymmetric catalysis;    ¥â-Keto phosphonates;    ¥â-Ketoesters;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The catalytic enantioselective electrophilic fluorinations of active methine compounds promoted chiral palladium complexes have been developed. Treatment of �?-keto phosphonates and �?-ketoesters with N-fluorobenzenesulfonimide as the fluorine source under mild reaction conditions afforded the corresponding �?-fluorinated adducts in high yields with excellent enantiomeric excesses (up to 99% ee). These reactions can be conducted in alcoholic solvents without any precaution to exclude water and moisture.

【 授权许可】

Unknown