Acetate-Promoted Aldol-Type Reaction: Scope and Reactivity of Acetates and Aldehydes

Bulletin of the Korean chemical society

Byeong Seon Jeong¹  Eung Seok Lee¹  Yurngdong Jahng¹  Dong Hyeon Kim¹  A F M Motiur Rahman¹ 

关键词: Ammonium acetate;    Aldol;    2;    5-Bis-benzylidenecyclopentanone;    2;    6-Bis-benzylidenecyclohexanone;    Mackinazolinone;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Potential of acetates and related compounds in glacial acetic acid as a catalyst for aldol-type condensation reactions was examined. Reactions of cycloalkanones or selected heteroaromatics with aldehydes in presence of 10 mol% of various acetates in acetic acid afforded �?,メ`-bis(substituted-benzylidene)cycloalkanones and substituted-benzylidene-mackinazolinones, respectively, in good yields. Among the compounds tested, ammonium acetate is the best and effective especially towards the reactions of mackinazolinone and aliphatic aldehydes to afford 6-alkylidenemackinazolinones.

【 授权许可】

Unknown