MWCNT/Fibrin Bionanocomposites by in situ Enzymatic Polymerization

Bulletin of the Korean chemical society

Insung S Choi¹  Sung Yong Son¹  John Hulme¹  Jun Ho Jang¹  Hyun jong Paik¹  Jung Hun Han¹  Seong Soo A An¹  Mijin Kim¹  Sang min Cho¹  Yong Won Lee¹ 

关键词: Bionanocomposites;    Multiwalled carbon nanotube;    Transglutaminase-catalyzed polymerization;    Fibrinogen;    Fibrin;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In this work multiwalled carbon nanotube (MWCNT)/fibrin hybrid structures were synthesized via the transglutaminase- catalyzed polymerization of fibrinogen (FBG). Specifically, FBG was tethered onto oxidized MWCNTs by amide coupling, and the in situ polymerization of FBG to fibrin was performed by plasma transglutaminase (Factor XIIIa) in the presence of thrombin. The attached FBG was found to be biologically active and was polymerized to fibrin by thrombin and Factor XIIIa. MWCNT-FBG and MWCNT-Fibrin structures were characterized by FT-IR spectroscopy, transmission electron microscopy, and energy-dispersive X-ray (EDX) spectroscopy.

【 授权许可】

Unknown