Stereoselective Recognition of Amino Alcohols and Amino Acids by Carbonylurea- and Carbonyguanidinium-based Imine Receptors

Bulletin of the Korean chemical society

Kwan Mook Kim¹  Hoe Jin Yoon¹  Yun Soo Ahn¹  Raju Nandhakumar¹ 

关键词: Stereoselective recognition;    Imine receptor;    Chirality conversion;    Amino alcohol;    Amino acid;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

New receptors 1-3 that bind stereoselectively amino alcohols and convert chirality of amino acidsvia imine bond formation were synthesized. The receptors have uryl (1), thiouryl (2) and guanidinium (3) groups all with additional phenylcarbonyl motifs, which are effective hydrogen bonding donors and play a key role in the stereoselective recognitions. The stereoselectivities were measured from the integration of 1H NMR peaks. Compound 1 and 2 showed the stereoselectivities for the imine formation with amino alcohols (KR/KS) in the range of 2 ~ 4, and compound 3 in the range of 4 ~ 8. Chirality conversion efficienciesof 1-3 for amino acids, i.e. D/L ratio at equilibrium, are in the range of 1.5 ~ 5.6, showing a little higher efficiency with 3. The additional phenylcarbonyl motifs in 1-3 were revealed not to contribute to significant enhancement of the selectivities.

【 授权许可】

Unknown