Synthesis and NO Production Inhibitory Activities of Ursolic Acid and Oleanolic Acid Derivatives

Bulletin of the Korean chemical society

Yong Sup Lee¹  Sung Hyun Chung¹  Dong Hyun Kim¹  Tae Hoon Kwon¹  Bomi Lee¹ 

关键词: Ursolic acid;    Oleanolic acid;    Anti-inflammatory;    NO production;    Structural modification;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Structural modifications were performed on the C-3 and C-28 positions of ursolic acid and oleanolic acid and the NO production inhibitory activities of the resulting derivatives were evaluated. The SAR revealed that the ursolic acid and oleanolic acid derivatives 3a and 4a, which possessing methoxy group at C-3 position exhibit improved NO production inhibitory activity on LPS-induced RAW247 cells while showing less cytotoxicity than the parent compounds.

【 授权许可】

Unknown