Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives

Bulletin of the Korean chemical society

Yan Xia¹  Kyeong Lee¹  Kyung Hoon Min¹ 

关键词: Coumarins;    Decursin;    Prantschimgin;    Multidrug resistance;    P-glycoprotein;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

【 授权许可】

Unknown