¥á-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Bulletin of the Korean chemical society

Pramod B Shinde¹  Kyung Sook Bae¹  Mohamed Elbandy¹  Jongki Hong¹  Mi Ae Kim¹  Sang Mong Lee¹  Jee H Jung¹ 

关键词: Sponge-derived fungus;    Paecilomyces lilacinus;    Pyrones;    Cyclohexenones;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

New α-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5?12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 μg/mL.

【 授权许可】

Unknown