Effective Amidation of Carboxylic Acids Using(4,5-Dichloro-6-oxo-6H-pyridazin-1-yl)phosphoric Acid Diethyl Ester

Bulletin of the Korean chemical society

Seung-Beom Kang¹  Yong-Jin Yoon¹  Jeum-Jong Kim¹  Heung-Seop Yim¹  Ju-Eun Won¹  Ho-Kyun Kim¹  Min-Jung Kim¹  Sang-Gyeong Lee¹ 

关键词: (4;    5-Dichloro-6-oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester;    Coupling agent;    Pyridazinone;    Amidation;    Dipeptide;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

(4,5-Dichloro-6-oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester (3a) are efficient and selective coupling agents for the amidation of carboxylic acids. Amidation of aliphatic and aromatic carboxylic acids with aliphatic and aromatic amines using 3a under mild condition gave chemoselectively the corresponding amides in good to excellent yield. Three protected-dipeptides were also synthesized from N-BOC-Phe and O-Meamino acid hydrochlorides using 3a under mild condition.

【 授权许可】

Unknown