Reaction of Sodium Cyanoaluminum Hydride with Selected Organic Compounds Containing Representative Functional Groups

Bulletin of the Korean chemical society

Oh Oun Kwon¹  Seung Jin Park¹  Se Jin Yu¹  Ja Eun Yi¹  Jin Soon Cha¹  Min Young Roh¹ 

关键词: Sodium cyanoaluminum hydride;    Selective reduction;    Organic functional groups;    Systematic reduction study;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Sodium cyanoaluminum hydride (SCAH) was prepared by the reaction of aluminum hydride and sodium cyanide in tetrahydrofuran at room temperature, and the approximate rates and stoichiometry of the reaction with selected organic compounds containing representative functional groups under the standardized conditions (tetrahydrofuran, 0 oC) were studied in order to define the reducing characteristics of the reagent for selective reductions. The reducing ability of SCAH was also compared with that of the parent sodium aluminum hydride (SAH). Generally the reducing power of SCAH appears to be weaker than that of the parent SAH. However, the reduction patterns of both reagents are quite similar. Thus, the reagent readily reduces carbonyl compounds, epoxides, amides, nitriles, carboxylic acids and their acyl derivatives to the corresponding alcohols or amines.

【 授权许可】

Unknown