Preparation and Application of a New Liquid Chromatographic Chiral Stationary Phase Based on Cefaclor

Bulletin of the Korean chemical society

Hwan Sun Cho¹  Hyun Ju Ha¹  Myung Ho Hyun¹  Jong Sung Jin¹  Hee Jung Choi¹ 

关键词: Cefaclor;    Chiral stationary phase;    N-(3;    5-Dinitrobenzoyl)-¥á-amino acids;    O-Ethoxycarbonyl-2-hydroxycarboxylic acids;    3-Substituted 1;    4-benzodiazepine-2-ones;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new HPLC chiral stationary phase (CSP) was prepared by bonding N-(3,5-dinitrobenzoyl)cefaclor to silica gel. The effective �?-�? donor-acceptor interaction between the CSP and analytes was demonstrated to be important for the chiral recognition by applying the new CSP to the resolution of N-(substituted benzoyl)leucine ethyl esters and N-(substituted benzoyl)leucine propyl amides. The new CSP was also successfully applied to the resolution of anilide derivatives of N-acetyl-�?-amino acids, anilide derivatives of Oethoxycarbonyl- 2-hydroxycarboxylic acids and 3-substituted 1,4-benzodiazepin-2-ones.

【 授权许可】

Unknown