Synthesis of Methyl-substituted Bicyclic Carbanucleoside Analogs as Potential Antiherpetic Agents

Bulletin of the Korean chemical society

Hyung Rock Lee¹  Kyung Ran Kim¹  Ah Young Park¹  Lak Shin Jeong¹  Pusoon Chun¹  Won Hee Kim¹  Jin Ah Kang¹  Hyung Ryong Moon¹  Jang Ho Bae¹ 

关键词: Bicyclo[3.1.0]hexanone;    Intramolecular carbenoid cycloaddition;    Mitsunobu reaction;    Diastereoselective reduction;    North conformation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Novel bicyclo[3.1.0]hexanyl purine nucleoside analogues were synthesized as potential antiherpetic agents via a bicyclo[3.1.0]hexanol (�?)-8, which was prepared using a highly efficient carbenoid cycloaddition reaction. A highly diastereoselective reduction of ketone and a Mitsunobu reaction for the condensation of glycosyl donor (�?)-12 with 6-chloropurine were employed.

【 授权许可】

Unknown