Observations Made in Exploring a Pyridinium Salt Photochemical Approach to the Synthesis of (+)-Lactacystin

Bulletin of the Korean chemical society

Maozhen Gong¹  Patrick S. Mariano¹  Ung Chan Yoon¹  Jiwen Zhou¹ 

关键词: (+)-Lactacystin;    Cyclopenta-fused pyridinium salt;    Photochemistry;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The key step in a strategy for the synthesis of (+)-lactacystin involving photocyclization reaction of a cyclopenta-fused pyridinium salt has been probed by using a model substrate. Observations made in this effort led to the discovery of a highly unusual cascade process that leads to stereoselective formation of an interesting tricyclic carbamate. The results of this study are presented and discussed in the context of a (+)-lactacystin synthetic approach.

【 授权许可】

Unknown