Synthesis of 3,3-Difluoro-2-pyrrolidone Derivatives

Bulletin of the Korean chemical society

Soung-Ryual Ryu¹  Kyu-Yun Chai¹  Zhi-Feng Xie¹  Chang-Soo Jun¹  Tae-Ho Kwon¹  Sung-Kwan Kim¹ 

关键词: 3;    3-Difluoro-2-pyrrolidone;    ¥á;    ¥á-Difluoro-¥ã-lactam;    Difluoromethylene group;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Introduction of a difluoromethylene group into organic compounds has been observed to impart them with positive properties, as viewed by a wide range of industries. Here, synthesis of 3,3-difluoro-2-pyrrolidone derivatives (7) was accomplished by the reaction of ethyl 2,2-difluoro-4-iodo-4-(trimethylsilyl) butanolate (4) with primary amines followed by desilylation. The key intermediate (4) was prepared from the addition reaction of trimethylvinylsilane (3) to ethyl difluoroiodoacetate (2) in the presence of Cu(0). Ethyl difluoroiodoacetate (2) was prepared starting from ethyl bromodifluoroacetate (1) via Reformatsky-type reaction.

【 授权许可】

Unknown