An Efficient and Concise Synthesis of Biologically Interesting Pyranochromenes by Ethylenediamine Diacetate-Catalyzed Double Condensation of Substituted Trihydroxybenzenes to ¥á,¥â-Unsaturated Aldehydes and Application to Natural Product Analoges

Bulletin of the Korean chemical society

Xin Li¹  Yong Rok Lee¹ 

关键词: Pyranochromene;    Double condensation;    Trihydroxybenzenes;    Electrocyclization;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A new methodology for the preparation of pyranochromenes was developed starting from substituted trihydroxybenzenes. This methodology was applied successfully to the total synthesis of biologically interesting compounds, clusiaphenone A, octandrenolone, O-methyloctandrenolone, trans-3```,4```-dihydro- 3```,4```-dihydroxy-O-methyloctandrenolone, trans-3``,4``-dihydro-3``,4``-dihydroxy-O-methyloctandrenolone, flemiculosin, laxichalcone, and racemic 3-deoxy-Ms-II.

【 授权许可】

Unknown