Application of Microwave Activation Techniques to the N-Alkenyl Protection of Lactams

Bulletin of the Korean chemical society

Ki Won Kim¹  Ho Joon Lee¹  Chung Gi Kim¹  Tae Woo Kwon¹  Hee Sook Ahn¹  Suk Jin Song¹ 

关键词: Pyrrolidin-2-one;    Ethyl pyroglutamate;    N-Alkenylation;    Aldehyde condensation;    Microwave irradiation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Rapid and facile syntheses of N-alkenyl lactam series via condensation between lactams and a variety of aldehydes such as n-propanal, isobutanal, n-butanal, n-hexanal, n-octanal and phenylacetaldehyde were studied under microwave or conventional heating. Various solid catalysts and solvents were examined to maximize the yields of condensation reactions.

【 授权许可】

Unknown