Asymmetric Cyanosilylation of Aldehydes by Chiral Ti-TADDOL Complex

Bulletin of the Korean chemical society

Gurusamy Rajagopal¹  Sung Soo Kim¹  Ju Myung Kwak¹ 

关键词: Cyanosilylation;    Aldehyde;    Ti-TADDOL;    Double activation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

A variety of chiral cyanohydrins were readily prepared from aldehydes with TMSCN under the influence of chiral titanium complex formed in situ from Ti(OiPr)4/TADDOL(I) in the presence of Ph3PO as additive. The double activation method produces trimethylsilylethers in excellent yield (95%) with moderate enantiomeric excess.

【 授权许可】

Unknown