Linear Correlation Equation for Retention Factor of Nucleic Acid Using QSPR

Bulletin of the Korean chemical society

Kyung Ho Row¹  Soon Koo Han¹  Jinzhu Zheng¹ 

关键词: Nucleic acid;    Retention factor;    QSPR;    Linear equation;    Correlation;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In the reversed-phase chromatography, the retention time of sample was investigated based on the molecular structure of compound. Several descriptors that were related to retention factors were selected, and then the values of descriptors were calculated with several softwares. The effect of retention factor was measured with calculated values, and the results were obtained that each descriptors of molecular structure of compound have different effect on the retention factor. Therefore, the empirical equation for seven types of descriptors considered was obtained, and it has high values of correlation coefficient. Furthermore, the experimental data and calculated values have good agreement.

【 授权许可】

Unknown