Bulletin of the Korean chemical society | |
An Efficient Synthesis of 2-Alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides | |
Saeed Ahmad1  Jamil Anwar Choudary1  Muhammad Zia-ur-Rehman1  | |
关键词: Ionic liquid; N-Alkylation; 1; 2-Benzothiazine-3-carboxamide; Piroxicam; Meloxicam; | |
DOI : | |
学科分类:化学(综合) | |
来源: Korean Chemical Society | |
【 摘 要 】
An efficient and environment friendly method has been described for the synthesis of various 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides starting from N-alkylation of sodium obenzosulfimide in an ionic liquid for the first time. Ring cleavage and ring closure of the resulting product were achieved in a single step in a cost effective solvent (methanol) followed by N-alkylation of resulting alkyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate in ionic liquid while boron triflouride was used as a catalyst along with molecular sieves in carboxamide formation step.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912010239591ZK.pdf | 899KB | download |