期刊论文详细信息
Bulletin of the Korean chemical society
An Efficient Synthesis of 2-Alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides
Saeed Ahmad1  Jamil Anwar Choudary1  Muhammad Zia-ur-Rehman1 
关键词: Ionic liquid;    N-Alkylation;    1;    2-Benzothiazine-3-carboxamide;    Piroxicam;    Meloxicam;   
DOI  :  
学科分类:化学(综合)
来源: Korean Chemical Society
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【 摘 要 】

An efficient and environment friendly method has been described for the synthesis of various 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides starting from N-alkylation of sodium obenzosulfimide in an ionic liquid for the first time. Ring cleavage and ring closure of the resulting product were achieved in a single step in a cost effective solvent (methanol) followed by N-alkylation of resulting alkyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate in ionic liquid while boron triflouride was used as a catalyst along with molecular sieves in carboxamide formation step.

【 授权许可】

Unknown   

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