Synthesis of Oxazolidinone Phosphonate Derivatives, Part I

Bulletin of the Korean chemical society

Jae-Min Hwang¹  Kang-Yeoun Jung¹  Woon-Seob Shin¹ 

关键词: Oxazolidinone;    Oxazolidinone phosphonates;    Antibacterial agent;    N-Arylation;    ¥ã-Ketophosphonate;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Several new derivatives of oxazolidinone phosphonate, that are expected to show biological activity, were prepared efficiently by previously published methods. �?-Ketophosphonate 1 was synthesized using pentacovalent oxaphosphorane chemistry followed by reductive amination with aromatic amine of oxazolidinone 4. Biological activity of the synthetic compounds has been studied. One of the synthetic compounds showed promising result for us to pursue further studies.

【 授权许可】

Unknown