Synthesis of Certain 6-(Arylthio)uracils and Related Derivatives as Potential Antiviral Agents

Bulletin of the Korean chemical society

Eman R. El-Bendary¹  Mohamed A. M. Massoud¹  Magda A. El-Sayed¹  Ali A. El-Emam¹ 

关键词: Substituted uracils;    Benzothiopyrano[2;    3-d]pyrimidine;    Pyrimido[5;    4-f]benzo[1;    4]thiazepines;    Antiviral activity;    Cytotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.

【 授权许可】

Unknown