Nucleophilic Substitution Reactions of Aryl Thiophene-2-carbodithioates with Pyridines in Acetonitrile

Bulletin of the Korean chemical society

Jae Myon Lee¹  Hyuck Keun Oh¹ 

关键词: Nucleophilic substitution reaction;    Pyridinolysis;    Cross-interaction constant;    Zwitterionic tetrahedral intermediate;    Stepwise mechanism;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The kinetics of reactions between Z-aryl thiophene-2-carbodithioates and X-pyridines in acetonitrile at 60.0 oC have been investigated. The Bronsted plots obtained for the pyridinolysis of aryl thiophene-2-carbodithioates are curved, with the center of curvature at pKa ~ 5.2 (pKao). The Bronsted plots for these nucleophilic reactions show a change in slope from a large ( モX . 0.78-0.87) to a small ( モX . 0.33-0.35) value, which can be attributed to a change in the rate-determining step from breakdown to formation of a zwitterionic tetrahedral intermediate in the reaction path as the basicity of the pyridine nucleophile increases. A clear-cut change in the crossinteraction constants, ヱXZ, from +0.92 to -0.23 supports the proposed mechanistic change. The breakpoint at pKa = 5.2 for R = thiophene ring in the present work is in agreement with those for the pyridinolysis of R = Me and 2-furyl, and attests to the insignificant effects of acyl group, R, on the breakpoint.

【 授权许可】

Unknown