Quaternized Polyamidoamine Dendrimers as Novel Gene Delivery System: Relationship between Degree of Quaternization and Their Influences

Bulletin of the Korean chemical society

Jung Hoon Lee¹  Yong-beom Lim¹  Jong-sang Park¹  Chul-hak Yang¹  Joon Sig Choi¹  Myung-un Choi¹ 

关键词: Gene delivery;    PAMAM;    Quaternary amine;    Cytotoxicity;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Quaternary ammonium groups were introduced to Starburst polyamidoamine (PAMAM) dendrimers for a gene carrier. These quaternary dendritic carriers exhibited reduced cytotoxicity on 293T cells compared to parent dendrimers examined and their transfection efficiency were similar with parent dendrimers. Quaternization could be a promising tool to improve properties of dendrimers as a gene delivery carrier.

【 授权许可】

Unknown