Protein Tyrosine Phosphatase 1B Inhibitors: Heterocyclic Carboxylic Acids

Bulletin of the Korean chemical society

Hyae Gyeong Cheon¹  Sang Sub Han¹  Joong-Kwon Choi¹  Jae Du Ha¹  Eun Young Shin¹  Ji Yoen Baek¹  Sung Soo Kim¹  Kwang Rok Kim¹  Seung Kyu Kang¹  Sung Yun Cho¹  Jin Hee Ahn¹ 

关键词: Diabetes;    PTP1B inhibitor;    Isoxazole;    Oxadiazole;    Quinoline;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Several series of compounds (benzoic acids, pyrazolecarboxylic acids, phenoxyacetic acids, and quinolinoxyacetic acids) were prepared and evaluated for their inhibitory activity against PTP-1B. Several compounds showed submicromolar inhibitory activity.

【 授权许可】

Unknown