A Facile One-Pot Operations of Reduction and Allylation of Nitrobenzaldehydes Mediated by Indium and Their Applications

Bulletin of the Korean chemical society

Moon Ho Chang¹  Hun Yeong Koh¹  Kyung Ho Kang¹  Yong Seo Cho¹  Ae Nim Pae¹  Joo Hwan Cha¹  Kyung Il Choi¹ 

关键词: Simultaneous reduction-allylation;    Indium;    Aqueous media;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Various nitrobenzaldehydes were simultaneously allylated and reduced using indium in the presence of HCl in aqueous media to give compounds having both functionality of homoallylic alcohol and aromatic amine. Sequential protection of the amino group and oxidation of the anilinyl homoallylic alcohol provided useful precursors of heterocyclic compounds such as dihydroindolones and dihydroquinolones, which could be efficiently synthesized through intramolecular cyclization reaction.

【 授权许可】

Unknown