Synthesis and Reactions of New Thienopyridines, Pyridothienopyrimidines and Pyridothienotriazines

Bulletin of the Korean chemical society

E. A. Bakhite¹  E. A. Thabet¹  A. E. Abdel-Rahman¹  O. S. Mohamed¹ 

关键词: Thienopyridines;    Pyrimidines;    Triazines;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

4-Aryl-3-cyano-6-(2`-thienyl)-pyridine-2(1H)-thiones (1a-c) were reacted with phenacyl bromide, chloro-N-arylacetamides or 2-chloroacetylaminopyridine to furnish 2-functionalized 3-amino-4-aryl-6-(2`-thienyl)-thieno[2,3-b]pyridines 4a-c and 5a-c or 5d respectively. The compounds 5a-d underwent different sequence of reactions to produce a variety of thienylpyridothienopyrimidines and, thienylpyridothienotriazines. Some of the prepared compounds were tested in vitro for their antimicrobial activities.

【 授权许可】

Unknown