Transformation of Carboxylic Acid Salts to Aldehydes by Stepwise Reduction with Borane and Oxidation with Pyridinium Chlorochromate

Bulletin of the Korean chemical society

Suk Joung Moon¹  Jin Soon Cha¹  Jae Hyung Park¹ 

关键词: Stepwise reduction-oxidation;    Borane reduction;    PCC oxidation;    Conversion of carboxlic acid salts to aldehydes;    Aldehyde synthesis.;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The stepwise reduction-oxidation method has been successfully applied to conversion of carboxylic acid salts to the corresponding aldehydes. Thus, both sodium and lithium salts of carboxylic acid were readily converted to aldehydes in essentially quantitative yields by stepwise treatment with borane and dimethyl sulfate, and followed by oxidation with PCC. Alternatively, the treatment of acid salts with two equivalents of borane in THF, and followed by the oxidation also provided the same results.

【 授权许可】

Unknown