Synthesis and characterization of polycaprolactone/acrylic acid (PCL/AA) hydrogel for controlled drug delivery

Bulletin of materials science

Sajid Majeed¹  Jahanzeb Mudassir¹  Nazar Mohammad Ranjha¹ 

[1] Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan$$Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, PakistanDepartment of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan$$

关键词: Polycaprolactone;    acrylic acid;    ethylene glycol dimethacrylate;    hydrogels;    tramadol.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

In the present work biodegradable pH-sensitive polycaprolactone/acrylic acid (PCL/AA) hydrogels have been developed using ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide as initiator. For these prepared hydrogels swelling studies, sol�?�gel fraction analysis and porosity measurements were performed. Results show that swelling of the hydrogels decreases on increasing the concentration of PCL and EGDMA, however swelling of hydrogels increases on increasing the concentration of AA. Results of sol�?�gel fraction analysis show that gel fraction increases on increasing concentration of monomer AA, polymer PCL as well as cross-linker EGDMA. As far as porosity is concerned, it increases on increasing the concentration of AA and PCL while porosity decreases on increasing the concentration of EGDMA. Hydrogels were characterized by measuring diffusion coefficient (𝐷) and equilibrium water content (EWC). Network formation, morphology and crystallinity of PCL/AA hydrogels were investigated using FTIR, SEM and XRD, respectively. Tramadol hydrochloride was loaded as model drug and its release pattern was analysed using various kinetic models like zero order, first order, Higuchi and Peppas. Results indicated that most of the samples followed non-Fickian release mechanism.

【 授权许可】

Unknown