Spectroscopic, thermal and biological studies of coordination compounds of sulfasalazine drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) transition metal complexes

Bulletin of materials science

M S Refat¹  M G Abd El-Wahed²  S M El-Megharbel² 

[1] Department of Chemistry, Faculty of Science, Port Said, Suez Canal University, Port Said, Egypt$$Department of Chemistry, Faculty of Science, Port Said, Suez Canal University, Port Said, EgyptDepartment of Chemistry, Faculty of Science, Port Said, Suez Canal University, Port Said, Egypt$$;Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt$$Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt$$

关键词: Infrared spectra;    electronic spectra;    thermal analysis;    sulfasalazine;    antimicrobial activity.;   

DOI  :  

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

The complexations of sulfasalazine (H₃Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)^-2(H₂O)₄].2H₂O, [M(HSuz)^-2(H₂O)₂].𝑥H₂O (M = Hg(II), ZrO(II) and VO(II), ð‘�? = 4, 8 and 6, respectively) and [M(HSuz)^-2(Cl)(H₂O)₃].𝑥H₂O (M = Cr(III) and Y(III), ð‘�? = 5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the sulfasalazine behaves as a monoanionic bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (ð›�? 𝐸^*}, ð›�? 𝐻^*, ð›�? ð‘�??^* and ð›�? 𝐺^*) were estimated using Coatsâ€�?�Redfern and Horowitzâ€�?�Metzger equations. In vitro antimicrobial activities of the H₃Suz and the complexes were tested.

【 授权许可】

Unknown