Formulation and in vitro Evaluation of Modified Release Oral Hydrogel Driven Drug Delivery Systems of Diethylcarbamazine Citrate

RGUHS Journal of Pharmaceutical Sciences

Raja Rajeswari Kamisetti¹  Winnie Vilasitha³  Durga Bhavani Penmatsa²  Sudhakar Muvvala³  Ramesh Alluri² 

[1] Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research (Affliated to JNTU, Hyderabad), Narsapur, Medak District, Telangana, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research (Affliated to JNTU, Hyderabad), Narsapur, Medak District, Telangana, India.Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research (Affliated to JNTU, Hyderabad), Narsapur, Medak District, Telangana, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research (Affliated to JNTU, Hyderabad), Narsapur, Medak District, Telangana, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.;Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.Department of Pharmaceutics, Malla Reddy College of Pharmacy (Affliated to Osmania University), Dhulapally, Maisammaguda, Secunderabad, India.

关键词: Hydrogels;    Ionotropic gelation;    Micro beads;    Modified release.;   

DOI  :  10.5530/rjps.2015.2.2

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Objective: Hydrogels are three dimensional polymer matrices that are capable of imbibing large quantity of water, and biological fluids and used in the modifying release of the drugs. The present work was aimed to study oral hydrogel driven drug delivery systems of Diethylcarbamazine Citrate as a model drug. Methodology: The Hydrogels were composed of Poly acrylamide, Hydroxyethyl methacrylate using ionotropic gelation method using starch. Results: Thermographs showed no incompatibility between the drug and the polymers. Scanning Electron photomicrographs showed a rough contour surface. Drug release studied by High Pressure Liquid Chromatography using acetonitrile/0•01M phosphate buffer pH 6•8 at 210 nm showed that Formulation 9 released 98.67% of the dose in 16 h as compared to the marketed formulation which released 98.66% up to 6 h. The release followed first order kinetics and non-fickian diffusion by super case-II transport mechanism. Accelerated stability studies performed as per ICH guidelines at 40° ± 2° and 75 ± 5% RH and at ambient conditions of 25° ± 2° and 60 ± 5% RH showed that the hydrogel was stabile. Conclusion: It is concluded that hydrogel can be recommended as modified release dosage forms for industrial applications.

【 授权许可】

Unknown