Extraction and characterization of Hybiscus Rosa-Sinensis leaves mucilage for Pharmaceutical applications

RGUHS Journal of Pharmaceutical Sciences

Murthy V.S.N¹  Karpakavalli M¹  Prabakaran L² 

[1] Dept. of Pharmaceutics, R. R. College of Pharmacy, Chikkbanawara – Po, Bangalore – 560 090, Karnataka, India.Karpagam College of Pharmacy, Coimbatore – 641032, IndiaDept. of Pharmaceutics, R. R. College of Pharmacy, Chikkbanawara – Po, Bangalore – 560 090, Karnataka, India.Dept. of Pharmaceutics, R. R. College of Pharmacy, Chikkbanawara – Po, Bangalore – 560 090, Karnataka, India.Karpagam College of Pharmacy, Coimbatore – 641032, IndiaKarpagam College of Pharmacy, Coimbatore – 641032, IndiaDept. of Pharmaceutics, R. R. College of Pharmacy, Chikkbanawara – Po, Bangalore – 560 090, Karnataka, India.Karpagam College of Pharmacy, Coimbatore – 641032, India

关键词: Polysaccharide/Mucilage;    Solubility enhancement;    Suspending agent;    Poorly soluble drugs;    Viscosity;    Swelling.;   

DOI  :  10.5530/rjps.2011.3.10

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

The present research was related to a process of production of crude, pharmaceutically useful dry water soluble mucilage/polysaccharide from leaves of hybiscus rosa-sinensis. Extraction of water soluble mucilage/polysaccharide from leaves was performed using water, phosphate buffer solutions of pH 4.0, pH6.8 and pH 9.2 as solvents for better yield. Physicochemical characterizations and other studies such as viscosity and effect of temperature on viscosity, pH, swelling in different physiological pH conditions were discussed. The dry water soluble mucilage/polysaccharide was then used as suspending agent and solubility enhancing agent to improve the bioavailability of some model drugs which are poorly soluble in water. Highest percent yield of the dry water soluble mucilage/polysaccharide was obtained in distilled/demineralized water (14.7%) and phosphate buffer pH 9.2 (16.4%). Powder characterization study (26.32°, 0.54 g/mL, 0.73 g/mL, 22.62%, and 1.08 of angle of repose, lose bulk density, tapped bulk density, carr's index and hausner's ratio respectively) ensured the mucilage/polysaccharide suitable for Tablet formulation and higher viscosity and swelling index at distilled/demineralized water and phosphate buffer pH 7.4 respectively ensures the suitability for suspension formulation (1.0% solution gave 356cps). Hence, the extracted dry water soluble mucilage/polysaccharide from leaves of hybiscus rosa-sinensis would be useful for pharmaceutical applications with economic, toxic less and biocompatible.

【 授权许可】

Unknown